Department of Cardiothoracic Surgery, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. Espeed.Khoshbin1@nhs.net. School of Health and Medicine, Lancaster University, Bailing, Upper Market Street, Lancaster, Lancashire, LA1 4YW, UK. Renal Unit, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Fulwood, Preston, Lancashire, PR2 9HT, UK. Department of Cardiothoracic Surgery, Blackpool Victoria Hospital, Blackpool, FY3 8NR, UK. Department of Cardiothoracic Surgery, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. Department of Public Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Headington, Oxford, OX3 7LF, UK. Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK.